IGNOU BBCS 185 SOLVED ASSIGNMENT HINDI

Ques 1.

जैवसूचना विज्ञान के दायरे की व्याख्या कीजिए और जीनोमिक्स, प्रोटिओमिक्स और सिस्टम बायोलॉजी में इसकी भूमिका का वर्णन कीजिए। 

Ques 2.

उपयुक्त उदाहरणों के साथ जैविक डेटाबेस को प्राथमिक, द्वितीयक और मिश्रित डेटाबेस में वर्गीकृत कीजिए। 

Ques 3.

अनुक्रम विश्लेषण में समानता, पहचान और समरूपता को परिभाषित कीजिए और अनुक्रम संरेखण में उनके महत्व की व्याख्या कीजिए। 

Ques 4.

युग्म–वार और बहु–अनुक्रम संरेखण के सिद्धांतों का वर्णन कीजिए और वैश्विक और स्थानीय संरेखण के बीच अंतर स्पष्ट कीजिए। 

Ques 5.

अनुक्रम विश्लेषण में PAM और BLOSUM जैसे अमीनो अम्ल प्रतिस्थापन मैट्रिक्स की संरचना और महत्व की व्याख्या कीजिए। 

Ques 6.

कंप्यूटर-सहायता प्राप्त औषधि डिजाइन में जैवसूचना विज्ञान उपकरणों और डेटाबेस के उपयोग का वर्णन करें, संरचना-आधारित और लिगैंड-आधारित दृष्टिकोणों पर प्रकाश डालते हुए। 

Ques 7.

NCBI से जीन या प्रोटीन अनुक्रम प्राप्त करने और ब्लास्ट का उपयोग करके इसका विश्लेषण करने में शामिल चरणों की व्याख्या करें। 

Ques 8.

कोशिकीय चयापचय और रोग मार्गों को समझने में KEGG और मेटासाइक जैसे चयापचय मार्ग डेटाबेस के उपयोग पर चर्चा करें। 

Ques 9.

CLUSTALW का उपयोग करके बहु अनुक्रम संरेखण को प्रोटीन के बीच विकासवादी संबंधों का अध्ययन करने के लिए कैसे लागू किया जा सकता है, इसकी व्याख्या करें।

Ques 10.

PDB से प्रोटीन संरचना डाउनलोड करने और पायमॉल का उपयोग करके इसे देखने के लिए व्यावहारिक कार्यप्रणाली का वर्णन करें, जिसमें आणविक फाइल स्वरूपों की भूमिका भी शामिल है। 

Ques 11.

Explain the scope of bioinformatics and describe its role in genomics, proteomics, and systems biology.

Ques 12.

Classify biological databases into primary, secondary, and composite databases with suitable examples.

Ques 13.

Define similarity, identity, and homology in sequence analysis and explain their significance in sequence alignment.

Ques 14.

Describe the principles of pairwise and multiple sequence alignment and differentiate between global and local alignment.

Ques 15.

Describe the principles of pairwise and multiple sequence alignment and differentiate between global and local alignment.

Ques 16.

 Explain the structure and importance of amino acid substitution matrices such as PAM and BLOSUM in sequence analysis

Ques 17.

Describe how bioinformatics tools and databases are used in computer-aided drug design, highlighting structure-based and ligand-based approaches.

Ques 18.

Explain the steps involved in retrieving a gene or protein sequence from NCBI and analyzing it using BLAST.

Ques 19.

Discuss the use of metabolic pathway databases such as KEGG and MetaCyc in understanding cellular metabolism and disease pathways.

Ques 20.

Explain how multiple sequence alignment using CLUSTALW can be applied to study evolutionary relationships among proteins.

Ques 21.

Describe the practical workflow for downloading a protein structure from the PDB and visualizing it using PyMol, including the role of molecular file formats.

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